Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups.

ABSTRACT:

Introduction

Type 2 diabetes mellitus (T2D) is a highly polygenic disease involving multiple biological pathways. Genetic ancestry may influence the predominant mechanisms driving T2D. Understanding how genetic background shapes T2D risk is crucial for developing personalized prevention and treatment strategies.

Methods

We analyzed ancestry-specific differences in T2D mechanisms and assessed the prevalence of T2D-associated genetic clusters, reflecting biological mechanisms underlying T2D onset and progression, in individuals from three Russian ancestry groups: Chechens, Tatars, and Yakuts. Previously developed polygenic scores were applied to evaluate cluster prevalence and clinical risk factors across ancestry groups.

Results

Cluster-specific polygenic scores varied

SUBMITTER: Markelova EE 

PROVIDER: S-EPMC12457129 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature