Novel perceptions of the involvement of CPZ in gastric cancer prognosis and immunomodulation.

ABSTRACT:

Background

Gastric cancer (GC) is a highly malignant tumor with a complex etiology. Most patients are diagnosed at an advanced stage with poor prognosis. The carboxypeptidase family is associated with progression in many cancers. Carboxypeptidase Z (CPZ) is a cellular matrix regulator. Corresponding studies on CPZ expression and the molecular mechanisms of GC prognosis and immunomodulation are lacking. We examined the influence of CPZ expression on the prognosis and immunomodulation of GC and the corresponding clinical significance.

Methods

CPZ gene expression in pan-cancer analysis was conducted using the Tumor Immune Estimation Resource (TIMER2.0) database. Differences in CPZ expression levels were investigated using 412 GC samples and 36 normal tissue samples from The Can

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC12457134 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature