Association of vitamin D with risk of dementia<i>:</i> a dose-response meta-analysis of observational studies.

ABSTRACT:

Background

The relationship between serum vitamin D levels and dementia risk remains unclear. This meta-analysis aims to evaluate the association and dose-response relationship between vitamin D levels and dementia risk.

Methods

A systematic literature search was conducted in Cochrane Library, PubMed, and Embase up to October 2024. A total of 22 studies comprising 53,122 participants were included. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random-effects models. A dose-response meta-analysis explored linear and non-linear relationships.

Results

Participants in the lowest vitamin D category had a 49% higher risk of dementia compared to those in the highest category (RR = 1.49, 95% CI: 1.32-1.67; I ² = 37.8%,

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12457182 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature