Jianpi-Huogu Prescription Repairs Nontraumatic Osteonecrosis of the Femoral Head by Inhibiting NAMPT/STK11/HMGCR/ACAT1 Axis-Mediated Lipid Production.

ABSTRACT: Jianpi-Huogu Prescription (JHP), integrating the classic Chinese herbal formulas Linggui-Zhugan Decoction and Si-Wu Decoction, has shown clinical efficacy in treating early nontraumatic osteonecrosis of the femoral head (NONFH). In this study, 299 chemical constituents of JHP were identified using ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry. Pharmacological evaluations in rats with early NONFH demonstrated that JHP attenuated femoral head pathological changes, improved gait parameters, increased mechanical pain thresholds, reduced serum levels of triglycerides, total cholesterol, low-density lipoprotein, very-low-density lipoprotein, and the TXB₂/6-keto-PGF₁α ratio while elevating high-density lipoprotein, decreased serum inflammatory cytokines (IL-1

SUBMITTER: Li T 

PROVIDER: S-EPMC12457209 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature