Tubulointerstitial nephritis with predominant monotypic plasma cell infiltration in three cases of Sjogren's syndrome: case reports and literature review.

ABSTRACT: Tubulointerstitial nephritis (TIN) is a common kidney manifestation of Sjögren's syndrome, typically characterized by interstitial infiltration of T and B cells, with plasma cells being more prominent than in other etiologies. While most plasma cell infiltration in TIN is polytypic and the importance of the immunoglobulin isotypes expressed by the infiltrating plasma cells in the pathogenesis is unknown, recent reports have identified rare cases with monotypic IgA-positive plasma cell infiltration accompanied by monoclonal gammopathy of undetermined significance (MGUS). Here, we present three cases of Sjögren syndrome-associated TIN characterized by monotypic plasma cell infiltration. In all cases, the isotype of the infiltrating plasma cells was consistent with that of the predominant ser

SUBMITTER: Miyauchi H 

PROVIDER: S-EPMC12457239 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature