Dynamic contrast-enhanced ultrasound perfusion analysis for preoperative prediction of aggressive hepatocellular carcinoma subtypes.

ABSTRACT:

Objective

To evaluate the potential of dynamic contrast-enhanced ultrasound (CEUS) quantitative parameters in preoperative prediction of macrotrabecular-massive (MTM) subtype and high Ki-67 pattern in hepatocellular carcinoma (HCC) patients.

Materials and methods

This study included a retrospective primary cohort and a multicenter prospective validation cohort comprising HCC patients who underwent surgical resection and preoperative CEUS between January 2023 and April 2024. The Clinic-CEUS model was established by combining clinical data and CEUS features, while the Clinic-Q-CEUS model was constructed by combining clinical data and CEUS features with matched quantitative parameters. Model performance was tested with the area under the receiver operating characteristic curve

SUBMITTER: Guan X 

PROVIDER: S-EPMC12457242 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature