MRI-derived radiomics model for predicting intratumoral tertiary lymphoid structures in soft tissue sarcoma.

ABSTRACT:

Objectives

To develop and validate an MRI-derived radiomics model for the prediction of intratumoral tertiary lymphoid structures (TLSs) status of soft tissue sarcoma (STS) and explore its prognostic value.

Materials and methods

This study retrospectively included 302 patients of three cohorts who underwent surgical resection of STS from two medical centers. Radiomics features were derived for both intratumoral and peritumoral regions from preoperative axial fat-suppressed T2-weighted and T1-weighted imaging sequences. Intratumoral, peritumoral, and combined radiomics models were constructed using a logistic regression algorithm. The area under the receiver operator characteristic curve (AUC) and the DeLong test were utilized to assess and compare the performances of three r

SUBMITTER: Wang T 

PROVIDER: S-EPMC12457251 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature