A case of acute tubulointerstitial nephritis with suspected Saikokaryukotsuboreito involvement responding to glucocorticoid therapy.

ABSTRACT: Drug-induced kidney injury is a major cause of acute tubulointerstitial nephritis (AIN). The standard treatment for AIN is discontinuation of the causative agent; however, if discontinuation alone is insufficient, glucocorticoid therapy may be effective. A 51-year-old woman was admitted to our hospital with acute kidney injury, presenting with an estimated glomerular filtration rate (eGFR) of 6.3 mL/min/1.73m². She was diagnosed with AIN after a renal biopsy. Drug-induced lymphocyte stimulation tests were performed on the herbal medicine she had been taking for 5 months, Saikokaryukotsuboreito (comprising Bupleurum root, Pinellia tuber, Scutellaria root, and Ginseng as key ingredients). The test results were positive for all four components. The patient discontinued the causativ

SUBMITTER: Ishibashi S 

PROVIDER: S-EPMC12457270 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature