Association of <i>FCGR2A</i> rs1801274 and <i>FCGR3A</i> rs396991 polymorphisms with various autoimmune diseases: a meta-analysis.

ABSTRACT:

Objectives

The aim of this systematic review with meta-analysis was to examine the association between the polymorphisms rs1801274 (FCGR2A H131R) and rs396991 (FCGR3A F158V) and susceptibility to autoimmune diseases (ADs), with a focus on the progress and novelty of studies published over the last two decades.

Methods

A meta-analysis systematically evaluated FCGR2A/3A gene variants in autoimmune diseases (ADs) using four genetic models: dominant, recessive, overdominant, and allelic contrast.

Results

The FCGR3A F158V polymorphism was significantly associated with immune thrombocytopenia in all four genetic models tested (dominant: OR = 2.67, 95% CI 1.94-3.67, for FV + VV vs. FF, recessive: OR = 2.38, 95% CI 1.78-3.19, for VV vs. FF + FV, ov

SUBMITTER: Thaler E 

PROVIDER: S-EPMC12457292 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature