Real-world treatment patterns and clinical outcomes among elderly patients with locoregionally advanced head and neck squamous cell carcinoma in the United States.

ABSTRACT:

Introduction

Multimodal therapy, including resection followed by adjuvant radiotherapy (RT) ± systemic therapy (ST) or definitive RT ± ST, is typically recommended for patients with locoregionally advanced head and neck squamous cell carcinoma (LA HNSCC) treated with curative intent. We assessed the real-world use of various treatment modalities and associated survival outcomes among elderly patients with LA HNSCC who received surgical or non-surgical primary treatment.

Methods

Linked SEER-Medicare data were used in this retrospective cohort study. Patients with newly diagnosed stage III-IVB LA HNSCC (larynx, hypopharynx, oral cavity, or oropharynx) from 2007-2019 who received primary treatment within 4 months after initial diagnosis were included. Real-world event-free surv

SUBMITTER: Zheng D 

PROVIDER: S-EPMC12457382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature