External validation of pathological T adjustments in the ninth edition of the pleural mesothelioma tumor-node-metastasis classification.

ABSTRACT:

Introduction

In the ninth edition pleural mesothelioma (PM) pathological (p) T staging, patients with fissural invasion are upgraded from T1 to T2. This study aimed to externally validate this staging modification.

Methods

Resected pT1/2 PM patients were selected. The Kaplan-Meier method was applied to assess survival differences, and propensity score matching was utilized to balance baseline characteristics. Univariable and multivariable Cox analyses were conducted to determine prognostic factors. Multiple model parameters were used to evaluate the performance of the ninth and eighth edition pT staging in distinguishing between T1 and T2 patients.

Results

A total of 818 eligible patients were included, among whom 325 initially classified as T1 were reclassified as T2

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12457411 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature