Dose-dependent interaction of dietary vitamin B2 and E in relation to cognitive performance: a cross-sectional study of older adults.

ABSTRACT:

Background

While individual associations of dietary vitamins with cognitive function have been widely studied, the combined role of vitamin B2 and E remains poorly understood. This study investigates their interactive effects on cognitive performance in older adults.

Methods

In this cross-sectional analysis of 2,497 participants (age ≥60 years) from NHANES 2011-2014, cognitive function was assessed using the Digit Symbol Substitution Test (DSST), with low performance defined as DSST scores <33 (lowest quartile). Dietary intake of vitamins B2 and E was derived from two 24-h recalls. Multivariable logistic regression models adjusted for sociodemographic, lifestyle, and clinical covariates examined independent and joint associations, with interaction effects quantified using pr

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12457415 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature