Establishment of an anaplastic stratification signature for gastric cancer based on diverse regulated cell-death.

ABSTRACT:

Background

Gastric cancer is a common malignant tumor characterized by poor prognosis and limited therapeutic options. The combination of Regulated cell death inducers and enhancement of the immune therapeutic effect plays an important role in cancer treatment.

Methods

We downloaded and analyzed data from gastric cancer samples, collected 14 Regulated cell death-related genes and constructed a Regulated Cell Death-Related Index (RCDRI) by various machine learning methods. Based on the RCDRI, gastric cancer patients were divided into high RCDRI and low RCDRI groups, and the clinical characteristics, immune cell infiltration, chemotherapy response and immunotherapy response of gastric cancer patients were analyzed based on the RCDRI.

Results

The newly constructed RCDRI

SUBMITTER: Chen S 

PROVIDER: S-EPMC12457426 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature