Association Between Cumulative Atherogenic Index of Plasma and New-Onset Stroke Among Middle-Aged and Elderly Chinese Patients With Stages 0-3 Cardiovascular-Kidney-Metabolic Syndrome: A Longitudinal Cohort Study.

ABSTRACT:

Background

Cardiovascular-kidney-metabolic (CKM) syndrome represents the interaction among chronic kidney disease, cardiovascular disease, and metabolic disorders. However, the association between the cumulative atherogenic index of plasma (CumAIP) and the risk of incident stroke in individuals with CKM syndrome has not been fully established.

Methods

Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4674 participants were categorized into quartiles according to CumAIP values and further stratified by CKM syndrome stages (0-3). Multivariable Cox regression models were applied to examine the relationship between CumAIP and incident stroke, while restricted cubic spline (RCS) models were used to explore potential nonlinear associat

SUBMITTER: Sun M 

PROVIDER: S-EPMC12457722 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature