Neurofilament light (NfL) chain levels predict clinical decline in Alzheimer's disease: A systematic review and meta-analysis.

ABSTRACT:

Background

Regulatory approval of new investigational Alzheimer's disease (AD) therapies could be accelerated if reasonably likely surrogate endpoints could be used. Neurofilament light chain (NfL) has potential utility as a prognostic biomarker of neurodegeneration in AD.

Objective

To synthesize available evidence on the relationship between baseline NfL levels and longitudinal clinical decline.

Methods

A systematic literature review identified 19 eligible studies, contributing 37 longitudinal statistical models evaluating the association between baseline NfL (plasma or cerebrospinal fluid [CSF]) with subsequent clinical decline based on validated clinical scales including Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-Cognitive Subscale,

SUBMITTER: Thomas K 

PROVIDER: S-EPMC12457754 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature