Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions.

ABSTRACT: Insertions and deletions (indels) are known to preferentially encode intrinsically disordered regions (IDRs), regions that by themselves do not form unique three-dimensional structures. As we previously showed that long internal exons tend to encode IDRs, we decided to analyze how indels alter internal exons and affect IDRs of the encoded proteins. Here, we analyzed eight eukaryotes to select indels commonly observed in all variants ("fixed" indels). The fixed indels in internal exons mostly encode IDRs. Residue-wise ∼50% of the indels are attributable to alterations in tandem repeats. Deletion is generally more prevalent in long internal exons and in most species the same trend is detected in insertion. Tandem repeats occur preferentially in long internal exons, indicating that their alte

SUBMITTER: Homma K 

PROVIDER: S-EPMC12457776 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature