Stable Carbon Isotope Analysis of Perfluorooctanoic Acid (PFOA) by Microflow-High Pressure Liquid Chromatography-Orbitrap Mass Spectrometry.

ABSTRACT:

Rationale

As contamination of perfluoroalkyl and polyfluoroalkyl substances (PFAS) in the environment becomes better understood, it is increasingly important to develop forensic tools capable of tracing contamination to emission sources. Isotopic methods have been previously inaccessible for PFAS due to limitations of the instrumentation, but high-pressure liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap MS) through electrospray ionization (ESI) allows measurement of the isotopic composition of individual PFAS compounds, such as perfluorooctanoic acid (PFOA).

Methods

Six separate supplier-procured powders of PFOA were analyzed for their δ¹³C isotopic composition by microflow-HPLC-ESI-Orbitrap MS.

Results

The method presented repl

SUBMITTER: Wojtal PK 

PROVIDER: S-EPMC12457815 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature