Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls.

ABSTRACT:

Background

Immune system abnormalities including hypogammaglobulinemia and T-cell deficiency occur in humans with protein-losing enteropathy (PLE). It is unknown whether similar abnormalities occur in dogs with PLE.

Objective

To evaluate serum immunoglobulin (Ig) concentrations and immune cell populations in dogs with PLE (with histologic evidence of chronic inflammatory enteropathy, intestinal lymphangiectasia (IL), or both) compared to healthy controls (HC).

Animals

Eighteen dogs with PLE and 18 HC dogs.

Methods

Prospective study. Serum IgA, IgG, and IgM concentrations were measured via ELISA in treatment-naïve dogs with PLE and compared to concentrations in HC dogs. RNA gene expression of specific immune cell surface markers in peripheral blood mononuclear c

SUBMITTER: Moore E 

PROVIDER: S-EPMC12457864 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature