Neuroimaging markers of dementia across race/ethnicity and sex/gender using an intersectional approach within the HABS-HD cohort.

ABSTRACT:

Introduction

Racial/ethnic and sex/gender differences in neuroimaging markers of dementia have been previously explored, but rarely with an intersectional approach.

Methods

Using data from the Health and Aging Brain Study-Health Disparities cohort, we examined neuroimaging markers of dementia using both interaction between race/ethnicity and sex/gender and effect modification of race/ethnicity by sex/gender.

Results

We analyzed data from 3433 dementia-free participants with either magnetic resonance imaging or positron emission tomography (PET) data at baseline (mean [standard deviation] age: 65 [9] years, 36% non-Hispanic White [NHW], 27% Black, 37% Hispanic, and 63% women). Compared to NHW, Black men had lower global amyloid PET standardized uptake value ratio (SUVR

SUBMITTER: Caunca MR 

PROVIDER: S-EPMC12457918 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature