Cytotoxic T lymphocyte-associated protein 4 gene polymorphisms are associated with ANCA-associated vasculitis in the Guangxi population of China.

ABSTRACT:

Introduction

Heredity and epigenetic factors contribute to the pathogenesis of neutrophil-cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Cytotoxic T lymphocyte-associated protein 4 (CTLA-4), an inhibitory receptor regulating T-cell homeostasis and maintaining self-tolerance, has emerged as a key target for immune screening and therapeutics in autoimmunity and cancer. CTLA-4 is associated with various autoimmune diseases; however, the relationship between CTLA-4 polymorphisms and AAV in the Guangxi population of China remains underexplored. In the present case-control study, we evaluated the effects of CTLA-4 polymorphisms on AAV susceptibility in the Guangxi population of China.

Methods

A total of 343 patients with AAV and 343 healthy controls were recruited. High-

SUBMITTER: Bu K 

PROVIDER: S-EPMC12457943 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature