Platelet-derived microvesicles modulate the bioenergetic and inflammatory phenotype of human polymorphonuclear leukocytes.

ABSTRACT: Platelets release microvesicles (PMVs) into the extracellular milieu upon activation. PMVs retain various platelet components, including functional mitochondria, and actively participate in intercellular communication with immune cells such as polymorphonuclear leukocytes (PMNs). PMVs have been known to modulate the inflammatory response of PMNs under normal physiological condition. Despite growing interest in the transfer of biological material between immune cells, the mitochondrial content shuttling from PMVs to PMNs and the resulting effects have remained unclear. Using freshly isolated PMVs from healthy and consenting donors, we demonstrate that PMVs modulate both the bioenergetic and inflammatory phenotypes of the recipient immune cell. We first confirmed the mitochondrial content tr

SUBMITTER: Soucy MN 

PROVIDER: S-EPMC12457944 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature