Clinically meaningful changes in cognitive and functional outcomes in a population-based study of cognitive aging.

ABSTRACT:

Introduction

Research is limited regarding meaningful change thresholds for individual patients on clinical outcome assessments (COAs) frequently used in clinical trials for Alzheimer's disease and related dementias (ADRD), particularly in population-based studies early in the disease course.

Methods

There were 646 study participants in the population-based Mayo Clinic Study of Aging (MCSA), 54-99 years old (47% females), who developed the clinical syndromes of mild cognitive impairment (MCI) with complete data to establish clinically meaningful within-patient change thresholds in cognitive and functional COAs.

Results

Using the diagnosis of incident MCI as the anchor, mean (95% confidence interval [CI]) annualized estimates of change were: Clinical Dementia Rating (C

SUBMITTER: Aakre JA 

PROVIDER: S-EPMC12457950 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature