The Role of Structural Dispersity of Polymer Brushes in Determining the Colloidal Stability of Core-Shell Nanoparticles and Their Interaction with Anti-PEG Antibodies.

ABSTRACT: The structural dispersity of poly-[oligo-(ethylene glycol) methacrylate] (POEGMA) brushes critically influences the stabilization of Au nanoparticles (NPs) and their interactions with anti-PEG antibodies (APAs). Commercial oligo-(ethylene glycol) methacrylate (OEG _p MA) macromonomers are intrinsically polydisperse, featuring a distribution of ethylene glycol (EG) units spanning from n = 2 to n = 15. Flash chromatography was applied to isolate OEG ₈ MA with discrete length (n = 8)the most abundant species in commercial mixtures. Controlled radical polymerization of polydisperse and discrete monomer sources was subsequently applied to generate POEG _p MA and POEG ₈ MA, which feature heterogeneous and

SUBMITTER: Pavon C 

PROVIDER: S-EPMC12458011 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature