Short-term risk of psychiatric adverse events following COVID-19 vaccination: nationwide self-controlled case series study.

ABSTRACT:

Background

To date, little is known about the evidence of a potential risk of psychiatric adverse events following COVID-19 vaccination in large populations with adequate study design.

Aims

To investigate whether COVID-19 vaccination is associated with increased risk of psychiatric adverse events.

Method

We used South Korea's linkage database to obtain registry data and claims data from 2019 to 2021, and conducted a population-based self-controlled case series study including 11 751 806 individuals. Primary outcomes included anxiety/nervousness, mood disorders, perceptual disturbances/psychoses, aggression/behavioural disturbances, cognitive impairments and sleep disorders within 21 days of COVID-19 vaccination. Secondary outcomes were the stratified primary outcomes

SUBMITTER: Lee H 

PROVIDER: S-EPMC12458088 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature