A Pilot Study to Evaluate Neurodevelopmental Outcomes in a Pediatric Cohort With Genodermatoses.

ABSTRACT: Our study aimed to evaluate cognitive function in individuals with genetic skin disorders involving neuroectoderm (n = 8) compared to individuals with only ectoderm or mesoderm (n = 16) involvement. We hypothesized that neuroectodermal involvement would result in poorer neurocognitive performance. A prospective, cross-sectional pilot study of 24 participants evaluated cognition, adaptive skills, behavior, and quality of life (QoL) using neurodevelopmental tests. Participants' characteristics and outcomes of interest were summarized by standard descriptive statistics using means, standard deviation, median, and 95% confidence intervals. We found no differences between mean cognitive composite standard score, adaptive composite standard score, QoL raw score, or internalizing and externalizin

SUBMITTER: Rangu SA 

PROVIDER: S-EPMC12458098 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature