Disruption of theta-timescale spiking impairs learning but spares hippocampal replay.

ABSTRACT: The ability to rapidly learn and retrieve salient information about new environments is critical for survival. In mammals, the hippocampus plays a crucial role in that learning. Specialized features of hippocampal population coding, including network-level theta oscillatory activity, location-specific firing of principal cells, and reactivation of experience during immobility (replay), have been implicated in rapid storage and retrieval of spatial information. Disruptions of theta and replay jointly, or replay alone, are sufficient to impair learning; however, the specific contribution of theta-associated temporal structure during locomotion remains unknown. In this study, we manipulated hippocampal spiking activity in rats specifically during locomotion by optogenetically activating septa

SUBMITTER: Joshi A 

PROVIDER: S-EPMC12458185 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature