PDLIM2 Repression: A Common Mechanism in Viral Lung Infection.

ABSTRACT:

Background

PDLIM2, a PDZ-LIM domain-containing protein expressed highest in the lung and immune cells, serves as a unique tumor suppressor and immune modulator, mainly by turning off the activation of the master transcription factors NF-κB and STAT3. While its role in cancer is established, the involvement of PDLIM2 in viral infection remains unclear.

Results

Here, we analyzed public gene expression data of blood leukocytes, bronchoalveolar lavage cells, and lung tissues from uninfected healthy humans and those infected with the respiratory virus SARS-CoV-2 or influenza. We found that PDLIM2 expression was repressed by viral infection, and notably, this repression correlated with the severity of infectious diseases. Consistently, the expression level of PDLIM2 was negatively

SUBMITTER: Gao F 

PROVIDER: S-EPMC12458227 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature