Geometric constraints on the architecture of mammalian cortical connectomes.

ABSTRACT: The intricate network of axonal fibres that forms the mammalian cortical connectome has a complex topology, being organized in a way that is neither completely regular nor random, as well as a characteristic topography, in which specific anatomical locations are imbued with distinctive connectivity profiles. The mechanisms that give rise to such properties remain a mystery. Here, we formulate a simple analytic model derived from neural field theory that prioritizes physical constraints on connectome architecture by assuming that connectivity is preferentially concentrated between pairs of cortical locations that facilitate the excitation of resonant geometric modes of the cortex. We show that the model outperforms existing approaches in reproducing multiple topological and topographical pr

SUBMITTER: Normand F 

PROVIDER: S-EPMC12458297 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature