The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genes.

ABSTRACT: Disruption of circadian rhythms predisposes shift workers to many chronic conditions, including osteoporosis. However, the effects of disrupted circadian rhythms on bone remodeling remain largely unknown. Here, we show that one of the core circadian regulators PER1 inhibits osteoclastogenesis by upregulating genes involved in inflammation. The conditional knockout of Per1 in osteoclasts and related cells resulted in decreased bone mass in the femurs of mice, along with increased osteoclasts and decreased osteoblasts. Osteoclastogenesis was also promoted by Per1 depletion in vitro with 17 downregulated inflammatory genes. Eight of these genes were known to promote or inhibit osteoclastogenesis depending on the stage of osteoclastogenesis and the presence or absence of infectio

SUBMITTER: Katoku-Kikyo N 

PROVIDER: S-EPMC12458312 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature