Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy.

ABSTRACT: Immunotherapies have revolutionized cancer care in recent decades, but approved therapies often fail and currently only target specific steps in the generation of anti-cancer immune responses. Notably, the majority of approved immunotherapies do not target antigen processing and presentation, which are key steps in the development of immune responses and harbor potential as targets to improve immunotherapy. Here, we demonstrate that breast tumors induce locoregional lymph node impairment in antigen presentation-but not in antigen processing-which limits anti-cancer antigen-specific T cell responses. Inhibition of the locoregional T cell response was due to a tumor-mediated reduction of the cytokine IL1β in tumor draining lymph nodes, which impaired antigen presentation. Further, we tested

SUBMITTER: O'Melia MJ 

PROVIDER: S-EPMC12458325 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature