Rethinking the Estrogen Receptor Beta Dominance Hypothesis in Endometriosis: Insights from Single Cell RNA Sequencing Meta-analysis.

ABSTRACT:

Background

Endometriosis is a chronic, estrogen-dependent disease characterized by the presence of endometrial-like tissue growing outside the uterus. The molecular and clinical heterogeneity of endometriosis complicate diagnostic and treatment options -- diagnostic delays of seven to ten years are common and therapies often lack long-term efficacy. Estrogen signaling and estrogen receptor beta (ERβ) expression is thought to be increased in endometriosis, contributing to increased cell proliferation in lesions. The "ERβ dominance hypothesis" is a prevailing hypothesis in the field, setting ERβ as a high-priority therapeutic target. If effectively modulated, ERβ could be the first therapy to directly target lesion biology, rather than only managing symptoms.

Objectives

We aim

SUBMITTER: Heath A 

PROVIDER: S-EPMC12458327 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature