<i>Candida glabrata</i> replicating within macrophages experiences amino acid deprivation, DNA damage, and chromosome instability.

ABSTRACT: Macrophages, the central players of innate immunity, control invading microbes by encapsulating them inside the phagosome, a nutrient-poor, reactive oxidant species-rich organelle. Nevertheless, some microbes, including the opportunistic yeast pathogen Candida glabrata, noted for its karyotype diversity, rapid evolution of antifungal drug resistance, and lack of meiosis, can survive and even replicate inside macrophages. However, it is not fully understood how C. glabrata responds to macrophage engulfment, and it is unknown how this presumably DNA-damaging environment influences the pathogen's genome stability. In this study, we used comparative transcriptomics to identify amino acid starvation and DNA damage as conditions eliciting C. glabrata responses most similar t

SUBMITTER: Aptekmann AA 

PROVIDER: S-EPMC12458424 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature