Network dynamics underlying activity-timescale differences between cortical regions.

ABSTRACT: Network-level dynamics are thought to be central to computation in the cerebral cortex. Yet, how these dynamics differ across areas remains poorly understood. We leveraged an intrinsic property of cortical regions to tackle this problem - the timescales over which they spontaneously sustain activity. We first co-registered functional and spatial transcriptomics datasets to show that timescales across the mouse cortex are predicted by many transcript categories, including those that regulate circuit wiring. Next, we used simultaneous two-photon imaging and optogenetics in mice to ask how these putative differences in connectivity lead to distinct network responses to brief, focal excitatory input to a short-timescale visual area, VISp, and a long-timescale frontal area, MOs. MOs neurons wer

SUBMITTER: Canton-Josh JE 

PROVIDER: S-EPMC12458431 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature