A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease.

ABSTRACT: Polycystic kidney disease (PKD) arises from mutations in cilia-associated genes, such as PKD1 and PKD2, expressed in renal epithelial cells, leading to progressive kidney dysfunction and end-stage kidney disease (ESKD). PKD patients exhibit significant heterogeneity in disease progression, largely due to genetic and environmental modifiers. Like patients, mouse models of PKD also exhibit significant heterogeneity with regards to the gene mutated, age of disease onset, and rate of disease progression. To elucidate the cellular and molecular consequences of these variables, we constructed an integrated single-cell and spatial transcriptomics atlas across mouse models of PKD, mapping changes in cell type composition, gene expression, and intercellular signaling networks across t

SUBMITTER: Miller SJ 

PROVIDER: S-EPMC12458445 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature