Structural and Mechanistic Basis for Antibody Neutralization of the Measles Fusion Protein.

ABSTRACT: Measles virus (MeV) is a highly contagious viral pathogen and remains a major global health threat. Resurgent infections, driven by insufficient vaccine coverage, waning herd immunity, and the vulnerability of immunocompromised individuals, highlight the urgent need for effective countermeasures. Monoclonal antibodies (mAbs) represent a promising strategy, both as antiviral agents and as probes of viral entry mechanisms. While most vaccine-elicited neutralizing antibodies target the hemagglutinin (H) protein, emerging evidence suggests that antibodies against the fusion (F) protein are also potent inhibitors. Still, there is insufficient information on the target sites and activities of antibodies against the F protein. Like other class I fusion proteins, MeV F exists in a metastable prefu

SUBMITTER: Zyla DS 

PROVIDER: S-EPMC12458459 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature