<i>Trsp</i> is required by regulatory T cells to prevent lethal autoimmunity in mice.

ABSTRACT: Selenoproteins are involved in immune cell metabolism, yet the roles of these proteins in T cell development and function remain largely unknown. The Trsp gene encodes the selenocysteine tRNA (tRNA^Sec) required for translation of all selenoproteins. In this study, we found that Trsp was required for thymopoiesis, with the majority of tRNA^Sec-deficient T cells not progressing beyond double negative 3 stage, with egressed thymocytes undergoing peripheral homeostatic expansion. Trsp-deficient CD4⁺ T cells exhibited impairments in TCR and IL-2 signaling and did not cause inflammation in experimental models. On the other hand, Trsp-deficient regulatory T (Treg) cells exhibited defects in suppressive function ex vivo and Treg-sp

SUBMITTER: Jacobse J 

PROVIDER: S-EPMC12458461 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature