More severe history of childhood adversity is linked to greater surface area of induced secondary hyperalgesia.

ABSTRACT: Childhood adversity is linked to persistent pain in adulthood. Nociceptive upregulation may play a role in this relationship. We investigated whether childhood adversity is associated with measures of nociceptive processing, and whether these associations differ by sex. In this experimental observational study, we enrolled pain-free adults with varying severity of childhood adversity, scored on the Childhood Trauma Questionnaire-Short Form. Measures of nociceptive processing included the surface area and magnitude of induced secondary hyperalgesia, temporal summation, and conditioned pain modulation. We used linear regression to investigate whether childhood adversity was associated with increased surface area or magnitude of secondary hyperalgesia, increased temporal summation, or reduced

SUBMITTER: Bedwell GJ 

PROVIDER: S-EPMC12458492 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature