Tangible advantages of multi-stage brain motion compensation for PET imaging demonstrated in multiple studies.

ABSTRACT: Head motion is a persistent challenge in positron emission tomography (PET) brain imaging, reducing quantitative accuracy, degrading time-activity curves (TACs), and complicating kinetic modeling. We evaluated a fully automated, multi-stage motion compensation framework, COMBRA (Correction of Motion and BRain Alignment), across more than one hundred scans and four independent PET studies using different radiotracers (¹⁸F-MK-6240, ¹¹C-Raclopride, ¹¹C-PBR28, and ¹¹C-Martinostat). COMBRA implements a staged registration and reconstruction pipeline, enabling both inter-frame realignment and intra-frame motion-gated correction. It operates in a PET-driven mode but can incorporate magnetic resonance imaging (MRI)-based motion tracking when available. A

SUBMITTER: Efthimiou N 

PROVIDER: S-EPMC12458507 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature