The genetic architecture of fibromyalgia across 2.5 million individuals.

ABSTRACT: Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying the first 26 risk loci for fibromyalgia. The strongest association was with a coding variant in HTT , the causal gene for Huntington's disease. Gene prioritization implicated the HTT regulator GPR52 , as well as diverse genes with neural roles, including CAMKV , DCC , DRD2 / NCAM1 , MDGA2 , and CELF4 . Fibromyalgia heritability was exclusively enriched within brain tissues and neural cell types. Fibromyalgia showed strong, positive genetic correlation with a wide

SUBMITTER: Kerrebijn I 

PROVIDER: S-EPMC12458511 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature