Cross-sectional associations between lifecourse dementia risk factors, plasma neurodegenerative biomarkers, and cognition in older adults in India.

ABSTRACT:

Background

Plasma neurodegenerative biomarkers are a potential low-cost tool for studying Alzheimer's disease and dementia in population-based research, especially in low- and middle-income countries (LMIC). However, their associations with modifiable risk factors and utility as an outcome in epidemiologic studies remain unclear.

Objective

Our objective was to estimate the cross-sectional association between modifiable lifecourse risk factors for dementia and plasma-based neurodegenerative biomarkers, and to compare those with the associations between lifecourse risk factors and cognition in a population-representative Indian sample.

Methods

Using nationally representative data from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (N=1625, avera

SUBMITTER: Gao S 

PROVIDER: S-EPMC12458516 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature