Poor dream recall associates with Alzheimer's disease biomarkers and dementia risk.

ABSTRACT:

Introduction

Dreaming is subserved by the default mode network (DMN) and can be abolished by focal lesions within key regions. DMN dysfunction is promoted by pre-clinical Alzheimer's pathology and apolipoprotein E (APOE) ε4 carriage, but any effects of these on dreaming are unknown.

Methods

Associations between dream recall and APOE ε4 carriage and blood phosphorylated tau (p-tau) 217 levels were determined using data for 1049 cognitively normal adults. Associations between dream recall and cognitive decline and dementia risk were also investigated.

Results

Higher p-tau217 levels and APOE ε4 carriage were both associated with lower chances of dream recall, independently of memory test scores and other covariates. Not recalling dreams at baseline w

SUBMITTER: Lipnicki DM 

PROVIDER: S-EPMC12458517 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature