A High-Order Cumulant Extension of Quasi-Linkage Equilibrium.

ABSTRACT: A central question in evolutionary biology is how to quantitatively understand the dynamics of genetically diverse populations. Modeling the genotype distribution is challenging, as it ultimately requires tracking all correlations (or cumulants) among alleles at different loci. The quasi-linkage equilibrium (QLE) approximation simplifies this by assuming that correlations between alleles at different loci are weak - i.e., low linkage disequilibrium - allowing their dynamics to be modeled perturbatively. However, QLE breaks down under strong selection, significant epistatic interactions, or weak recombination. We extend the multilocus QLE framework to allow cumulants up to order K to evolve dynamically, while higher-order cumulants >K are assumed to equilibrate rapidly. This extended QLE (e

SUBMITTER: Shimagaki KS 

PROVIDER: S-EPMC12458595 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature