Altered Gastrointestinal Interoception in Anorexia Nervosa Predicts Relapse.

ABSTRACT: Anorexia nervosa (AN) is a deadly psychiatric disorder, yet relapse remains common after weight restoration and no objective tools exist to track recovery. AN involves profound disturbances of gastrointestinal interoception, but no clinical tests assess this dysfunction. In this single-blind, randomized-crossover study, 62 weight-restored females with restrictive AN and 57 matched healthy comparisons completed a gastrointestinal detection task using an ingestible vibrating capsule while behavioral, electroencephalographic, and peripheral physiological signals were recorded. AN participants showed reduced perceptual accuracy and higher miss-rates despite intact neural and physiological responses. Computational modeling revealed stronger prior beliefs against perceiving gut sensations, dimin

SUBMITTER: Verdonk C 

PROVIDER: S-EPMC12458608 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature