Immune-related adverse events occurring rapidly after a single dose of immune checkpoint blockade.

ABSTRACT:

Background

The optimal dosing regimen for immune checkpoint blockade (ICB) remains a critical question in oncology. Although immune-related adverse events (irAEs) are common with ICB, the incidence and severity of irAEs following a single dose of anti-programmed death-ligand 1 (PD-(L)1) blockade have not yet been investigated.

Methods

We conducted a single-center prospective cohort study at Gustave Roussy (Villejuif, France), based on a population of patients with advanced or metastatic cancer, using data from the French Registre des Effets Indésirables Sévères des Anticorps Monoclonaux (REISAMIC) registry, a pharmacovigilance database dedicated to irAEs. Between December 2014 and December 2023, we included adults with solid or hematologic malignancies who presented with irA

SUBMITTER: Guitton R 

PROVIDER: S-EPMC12458726 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature