Mixed methods implementation research of oral antiviral treatment for COVID-19 in low- and middle-income countries: a study protocol.

ABSTRACT:

Introduction

There is an absence of real-world evidence, especially from low- and middle-income countries (LMICs), on the implementation successes and challenges of COVID-19 Test and Treat (T&T) programmes. In 2022, nirmatrelvir/ritonavir was provided as standard of care for mild to moderate COVID-19 treatment in eight LMICs (Ghana, Kenya, Laos, Malawi, Nigeria, Rwanda, Uganda and Zambia). This manuscript describes a research protocol to study novel drug introduction during the COVID-19 health emergency, with implications and learnings for future pandemic preparedness. The goal of the study is to provide simultaneous programme learnings and improvements with programme rollout, to fill a gap in real-world implementation data on T&T programmes of oral antiviral treatment for COVID-19

SUBMITTER: Narayanasamy S 

PROVIDER: S-EPMC12458809 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature