Development and validation of LUPIN: a patient-centred self-administered tool to assess disease activity and patient-reported outcomes in systemic lupus erythematosus.

ABSTRACT:

Objective

To develop and validate LUPIN, a self-administered, patient-centred questionnaire codesigned by patients and lupus specialists to assess disease activity and patient-reported outcomes in systemic lupus erythematosus (SLE).

Methods

LUPIN and the SF-36 questionnaires were distributed across 34 centres in both metropolitan France and overseas territories. Patients completed the questionnaire prior to their consultations. Physicians, blinded to patients' responses, assessed disease activity using SLE Disease Activity Index 2000 (SLEDAI-2K) and Physician Global Assessment (PhGA). Correlations and discordances between patient and physician assessments were analysed.

Results

Among 444 participants (85% women, mean age 45 years), the most common manifestations inclu

SUBMITTER: Scherlinger M 

PROVIDER: S-EPMC12458825 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature