Serum calprotectin and complement factor C3 are superior biomarkers of inflammation in early psoriatic arthritis as compared with C-reactive protein.

ABSTRACT:

Objectives

C reactive protein (CRP) is frequently normal in psoriatic arthritis (PsA) despite active disease, complicating inflammation assessment. This study aimed to evaluate alternative biomarkers of inflammation in early PsA.

Methods

Adult patients with early, treatment-naïve PsA were enrolled in the prospective multicentre cohort and compared with early rheumatoid arthritis (RA) and healthy controls (HCs). Clinical assessments, inflammatory markers and peripheral blood counts were collected. For this study, baseline and 1-year data were used. Serum complement factor 3 (C3), calprotectin (S100A8/9) and serum amyloid A (SAA) were measured by ELISA. Discriminatory performance was evaluated using receiver operating characteristic curve analysis.

Results

A total of 67

SUBMITTER: Ishchenko A 

PROVIDER: S-EPMC12458838 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature