Association of small dense low-density lipoprotein cholesterol with cardiovascular risk in premature acute coronary syndrome and multivessel disease: a single-centre retrospective cross-sectional study.

ABSTRACT:

Objectives

Premature acute coronary syndrome (PACS) presents with a poor prognosis and significant risks. This study aimed to investigate the association between small-dense low-density lipoprotein cholesterol (sdLDL-C) levels and the severity of coronary lesions, as well as its potential role in risk stratification for PACS patients with multivessel disease (MVD).

Design

Retrospective cross-sectional study.

Setting

First Affiliated Hospital of Xinjiang Medical University in China, between May 2022 and November 2023.

Participants

900 PACS patients with MVD confirmed by coronary angiography (CAG) and 600 age-matched and sex-matched controls with normal CAG results.

Methods

Patients with PACS and MVD were stratified by the Global Registry of Acute Coronary

SUBMITTER: Keremu M 

PROVIDER: S-EPMC12458871 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature