Case Report: Trilostane therapy in a dog with recurrent adrenocortical carcinoma producing an array of steroid hormones.

ABSTRACT:

Case summary

A 10-year-old neutered male poodle-cross was presented with signs of progressive hyporexia and marked polyuria and polydipsia (PU/PD) of 2 months' duration. Right unilateral adrenalectomy was performed 24 months prior, and adrenocortical carcinoma with no evidence of metastatic disease was diagnosed. Tumor aldosterone secretion was suspected due to persistent hypokalaemia and systemic hypertension. Upon re-presentation, the dog had a pot-bellied appearance, dermatological changes (symmetrical alopecia along the trunk, elbows, and hocks, with decubital ulcers), systemic hypertension, and marked hypokalaemia unresponsive to oral potassium supplementation, raising concerns for an endocrine disorder. Abdominal CT confirmed mass lesions in multiple liver lobes near the prev

SUBMITTER: Cheung C 

PROVIDER: S-EPMC12458880 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature