Iron(III)-Mediated C-H Alkylation: One-Electron Differentiation Increases Activity and Chemoselectivity.

ABSTRACT: The C-H functionalization of arenes mediated by well-defined bis(phosphine)-supported organometallic iron(III) complexes is described. One-electron oxidation of trans-(depe)₂Fe(CH₃)₂ (depe = 1,2-bis(diethylphosphino)ethane) generated the corresponding isolable iron(III) dimethyl derivative that was unstable toward Fe-CH₃ homolysis. Oxidation of the corresponding iron(II) bis(aryl) complex trans-(depe)₂Fe(tolyl)₂ resulted in rapid reductive elimination of the biaryl with formation of iron(I). These observations motivated the synthesis of the cationic iron(III) metallacycle derived from C-H activation of a neophyl ligand. This complex mediated the ortho-selective C(sp²)-H alkylation of a host of

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12458898 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature